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The protein encoded by the SMPD1 gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq)
![Western Blot SMPD1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/SMPD1_AF5348_Western_Blot_5692.jpg)
![Simple Western SMPD1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af5348_human-smpd1-affinity-purified-polyclonal-ab-simple-western-1102021141358.jpg)
![Knockdown Validated SMPD1 Antibody (563418) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab5348_human-smpd1-mab-clone-563418-knockdown-validated-2882025154649.png)
![Immunoprecipitation SMPD1 Antibody (563418) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab5348_human-smpd1-mab-clone-563418-immunoprecipitation-288202516647.png)
