SLX4 Products

Description

SLX4 (also known as BTBD12 and FANCP) is a multidomain scaffold protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. SLX4 hat interacts with three distinct nucleases: SLX1, ERCC4/XPF-ERCC1 and MUS81-EME1. Mutations in the gene are associated with the disease Fanconi anemia, a rare recessive disorder characterized by genome instability, congenital malformations, progressive bone marrow failure and predisposition to hematologic malignancies and solid tumors.

Bioinformatics

Product By Gene ID	84464
Alternate Names	BTB (POZ) domain containing 12 BTB/POZ domain-containing protein 12 BTBD12 BTBD12structure-specific endonuclease subunit SLX4 FANCP KIAA1784 KIAA1784MUS312 KIAA1987 KIAA1987FANCP SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) SLX4

Related SLX4 Blog Posts

Check out the latest blog posts on SLX4.

FANCD2 (Fanconi anemia subunit D2 protein) Fanconi anemia (FANC) is a rare, autosomal-recessive genetic disorder that is a heterogeneous cancer susceptibility condition that manifests with a wide range of symptoms such as congenital malformations, deteriorating bone marrow failure, DNA-dama...    Read more.

FANCD2: A big component of the DNA repair crew The genetic disorder known as Fanconi anemia (FANC) is a heterogeneous, autosomal-recessive cancer susceptibility condition characterized by a wide array of symptoms. These include congenital malformations, progressive bone marrow failure, DNA-damage ...    Read more.

Read more SLX4 related blogs.