Slit1 Products

Antibodies
Slit1 Antibody
Slit1 Antibody
NB600-880
Species: Mu, Rt
Applications: WB, ELISA
Host: Rabbit Polyclonal
RNAi
Slit1 RNAi
Slit1 RNAi
H00006585-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 6585
Alternate Names
  • KIAA0813
  • Multiple epidermal growth factor-like domains protein 4
  • slit homolog 1 protein
  • Multiple EGF-like domains protein 4
  • MGC164811
  • SLIT3
  • Slit-1slit1
  • MEGF4slit (Drosophila) homolog 1
  • SLIL1
  • slit homolog 1 (Drosophila)

Research Areas for Slit1

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers
Neuroscience
Signal Transduction

PTMs for Slit1

Learn more about PTMs related to Slit1.

Methylation
Cleavage
Glycosylation

Bioinformatics Tool for Slit1

Discover related pathways, diseases and genes to Slit1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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