Siglec-2/CD22 Products

Description

CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha).

Bioinformatics

Entrez	933 Human
Product By Gene ID	933
Alternate Names	B-cell receptor CD22 BL-CAM B-lymphocyte cell adhesion molecule CD22 antigenMGC130020 CD22 molecule CD22 sialic acid binding Ig-like lectin 2 Sialic acid-binding Ig-like lectin 2 Siglec2 Siglec-2 SIGLEC2FLJ22814 T-cell surface antigen Leu-14

Research Areas for Siglec-2/CD22

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Adaptive Immunity
Immunology

Related Siglec-2/CD22 Blog Posts

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Antigen-loss relapse after successful CAR-T therapy; What do we do now? By Jacqueline Carrico, BS, MD Tumor cell mechanisms driving tolerance to CAR-T Despite very promising results of CAR-T therapy in acute lymphoblastic leukemia, B-ALL, antigen-loss relapse has arisen as a major chall...    Read more.

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