SHFM3 Products

Antibodies
SHFM3 Antibody
SHFM3 Antibody
NBP2-14013
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SHFM3 Antibody
SHFM3 Antibody
NBP1-02491
Species: Hu
Applications: ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
SHFM3 Antibody
SHFM3 Antibody
H00006468-B01P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Lysates
SHFM3 Overexpression Lysate ( ...
SHFM3 Overexpression Lysate (Denat...
H00006468-T01
Species: Hu
Applications: WB
SHFM3 Overexpression Lysate ( ...
SHFM3 Overexpression Lysate (Native)
NBP2-06483
Applications: WB
Proteins
SHFM3 Partial Recombinant Pro ...
SHFM3 Partial Recombinant Protein
H00006468-Q01
Species: Hu
Applications: WB, ELISA, PA
SHFM3 Recombinant Protein Ant ...
SHFM3 Recombinant Protein Antigen
NBP2-14013PEP
Species: Hu
Applications: AC
RNAi
SHFM3 RNAi
SHFM3 RNAi
H00006468-R01
Species: Hu

Description

SHFM3 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 6468
Alternate Names
  • FBWD4
  • Dactylin
  • DAC
  • F-box/WD repeat-containing protein 4
  • F-box and WD-40 domain-containing protein 4
  • F-box/WD repeat protein 4
  • SHFM3
  • SHSF3
  • F-box and WD-40 domain protein 4
  • dactylin
  • FBW4split hand/foot malformation (ectrodactyly) type 3
  • Fbw4
  • F-box and WD repeat domain containing 4

Pathways for SHFM3

View related products by pathway and learn more about each of the pathways below.

Limb Development
Pathogenesis
Limb Morphogenesis
Proteolysis
Pigmentation
Localization

Research Areas for SHFM3

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for SHFM3

Learn more about PTMs related to SHFM3.

Methylation
Ubiquitination

Bioinformatics Tool for SHFM3

Discover related pathways, diseases and genes to SHFM3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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