SHFM3 Products

SHFM3 Antibody
SHFM3 Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SHFM3 Antibody
SHFM3 Antibody
Species: Hu, Mu, Rt, Bv, Ca, Eq, Gp, Rb
Applications: WB
Host: Rabbit Polyclonal
SHFM3 Antibody
SHFM3 Antibody
Species: Hu
Applications: WB
Host: Mouse Polyclonal
SHFM3 Overexpression Lysate
SHFM3 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human SHFM3 GST ( ...
Recombinant Human SHFM3 GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
SHFM3 Recombinant Protein Ant ...
SHFM3 Recombinant Protein Antigen
Species: Hu
Applications: AC


SHFM3 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq]


Entrez Human
Uniprot Human
Product By Gene ID 6468
Alternate Names
  • FBWD4
  • Dactylin
  • DAC
  • F-box/WD repeat-containing protein 4
  • F-box and WD-40 domain-containing protein 4
  • F-box/WD repeat protein 4
  • SHFM3
  • SHSF3
  • F-box and WD-40 domain protein 4
  • dactylin
  • FBW4split hand/foot malformation (ectrodactyly) type 3
  • Fbw4
  • F-box and WD repeat domain containing 4

Pathways for SHFM3

View related products by pathway and learn more about each of the pathways below.

Limb Development
Limb Morphogenesis

Research Areas for SHFM3

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

PTMs for SHFM3

Learn more about PTMs related to SHFM3.


Bioinformatics Tool for SHFM3

Discover related pathways, diseases and genes to SHFM3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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