SHANK3 Products

Antibodies
SHANK3 Antibody (S69-46)
SHANK3 Antibody (S69-46)
NBP1-47610
Species: Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
SHANK3 Antibody
SHANK3 Antibody
NBP2-41171
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
SHANK3 Antibody (S367-51)
SHANK3 Antibody (S367-51)
NBP2-42189
Species: Rt, Human
Applications: WB, ICC/IF, IHC, ICC
Host: Mouse Monoclonal
Lysates
SHANK3 Overexpression Lysate ...
SHANK3 Overexpression Lysate (Native)
NBP2-08490

Description

The SHANK3 gene encodes a SH3 and multiple ankyrin repeat domain protein 3 that in isoform 1 is 1,741 amino acids long at 186 kDA and in isoform 2 is 1,732 amino acids long at 185 kDA. This protein functions as an adaptor in postsynaptic density of excitatory synapses. Through complexes that include GKAP/PSD-95 and Homer and the actin-based cytoskeleton, these excitatory synapses are connected with the postsynaptic membrane including NMDA-type and metabotropic glutamate receptor. Additionally, this protein may function in structural and organizational projects of the dendritic spine and the synaptic junction. SHANK3 gene participates in cytoplasmic microtubules, glutamatergic synapses, and signaling events regulated by ret tyrosine kinase. It is known to interact with genes PLCG1, FYN, SRC, ABL1, and PIK3R1. Defects in SHANK3 are associated with autism spectrum disorders and schizophrenia type 15. It is also associated with phelan-mcdermid syndrome, cerebritis, prostatitis, neuronitis, dementia, prostate cancer, hypogonadism, hepatitis a, jacobsen syndrome, and trisomy 22.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Rat
Product By Gene ID 85358
Alternate Names
  • PROSAP2
  • Shank3
  • DEL22q13.3
  • ProSAP2
  • Proline-rich synapse-associated protein 2
  • shank postsynaptic density protein
  • SPANK-2
  • PSAP2SH3 and multiple ankyrin repeat domains protein 3
  • KIAA1650proline rich synapse associated protein 2
  • prosap2
  • SH3 and multiple ankyrin repeat domains 3

PTMs for SHANK3

Learn more about PTMs related to SHANK3.

Phosphorylation
Methylation
Cleavage

Bioinformatics Tool for SHANK3

Discover related pathways, diseases and genes to SHANK3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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