SFRS8 Products

Description

SFRS8 regulates the splicing of CD45, a protein which through alternative splice variants, has an essential role in activating T cells. T cells are involved in the pathogenesis of atopic diseases such as asthma, making SFRS8 a very interesting candidate gene in the region. SFRS8 could act as a weak predisposing gene for asthma. [from: http://www.ncbi.nlm.nih.gov/sites/entrez®cmd=Retrieve&db=PubMed&list_uids=16738036&dopt=Abstract] The basic functions of SFRS8 are the mediation of protein-protein interactions within the intron during spliceosome assembly, independently binding to exonic enhancer sequences, and recruiting components to adjacent introns for splice-site recognition and alternative splicing. [from: http://www.dsi.univ-paris5.fr/genatlas/fiche1.php®symbol=SFRS8]

Bioinformatics

Entrez	6433 Human
Uniprot	Q12872 Human NP_004583.2 Human B2RN45 Human
Product By Gene ID	6433
Alternate Names	Suppressor of white apricot protein homolog Splicing factor, arginine/serine-rich 8 Drosophila homolog) splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot splicing factor, suppressor of white-apricot homolog Drosophila) splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog SWAPMGC167082 SFRS8 splicing factor, suppressor of white-apricot homolog (Drosophila)

Diseases related to SFRS8

Discover more about diseases related to SFRS8.

Retinoblastoma
Hereditary Diseases
Nervousness
Asthma
Frontotemporal Dementia
Dementia
Dysequilibrium Syndrome

Pathways for SFRS8

View related products by pathway and learn more about each of the pathways below.

Protein Phosphorylation
Cell Activation
Mrna Splicing
T Cell Activation
Pathogenesis
Rna Interference
Chromatin Remodeling

PTMs for SFRS8

Learn more about PTMs related to SFRS8.

Phosphorylation

Bioinformatics Tool for SFRS8

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