SFRS8 Products

Description

SFRS8 regulates the splicing of CD45, a protein which through alternative splice variants, has an essential role in activating T cells. T cells are involved in the pathogenesis of atopic diseases such as asthma, making SFRS8 a very interesting candidate gene in the region. SFRS8 could act as a weak predisposing gene for asthma. [from: http://www.ncbi.nlm.nih.gov/sites/entrez®cmd=Retrieve&db=PubMed&list_uids=16738036&dopt=Abstract] The basic functions of SFRS8 are the mediation of protein-protein interactions within the intron during spliceosome assembly, independently binding to exonic enhancer sequences, and recruiting components to adjacent introns for splice-site recognition and alternative splicing. [from: http://www.dsi.univ-paris5.fr/genatlas/fiche1.php®symbol=SFRS8]

Bioinformatics

Entrez	6433 Human
Uniprot	B2RN45 Human NP_004583.2 Human Q12872 Human
Product By Gene ID	6433
Alternate Names	Drosophila homolog) Drosophila) SFRS8 splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot Splicing factor, arginine/serine-rich 8 splicing factor, suppressor of white-apricot homolog (Drosophila) splicing factor, suppressor of white-apricot homolog Suppressor of white apricot protein homolog SWAPMGC167082