Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, KD
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Po, Bv
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, KD
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Human
Mouse
|
| Product By Gene ID |
6390 |
| Alternate Names |
- EC 1.3.5.1
- FLJ92337
- IP
- Ip
- Iron-sulfur subunit of complex II
- PGL4
- SDH
- SDH1
- SDH2
- SDHIP
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
|
Research Areas for SDHB
Find related products by research area and learn more about each of the different research areas below.
Cancer
Related SDHB Blog Posts
Check out the latest blog posts on SDHB.
HIF Antibodies: Beyond HIF-1 alpha
The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the... Read more.
|
Read more SDHB related blogs.
