Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, ICC/IF, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
SAP130 encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Bioinformatics
| Product By Gene ID |
23450 |
| Alternate Names |
- KIAA0017splicing factor 3b, subunit 3, 130kD
- Pre-mRNA-splicing factor SF3b 130 kDa subunit
- RSE1
- SAP130SAP 130
- SF3B130
- SF3b130pre-mRNA splicing factor SF3b, 130 kDa subunit
- Spliceosome-associated protein 130
- splicing factor 3B subunit 3
- splicing factor 3b, subunit 3, 130kDa
- STAF130
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