RUNX1T1/ETO Products

Description

RUNX1T1 / ETO is encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Bioinformatics

Entrez	862 Human
Uniprot	AAH05850 Human NM_175635 Human NM_175636 Human NP_004340 Human NP_004340.1 Human Q06455 Human
Product By Gene ID	862
Alternate Names	AML1T1protein CBFA2T1 CBFA2T1Cyclin-D-related protein CDRMGC2796 core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclinD-related DKFZp564B213 Eight twenty one protein ETOFLJ33145 MTG8acute myelogenous leukemia 1 translocation 1, cyclin-D related Protein ETO Protein MTG8 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Zinc finger MYND domain-containing protein 2 ZMYND2myeloid translocation gene on 8q22