Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
RUNX1T1 / ETO is encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Bioinformatics
| Product By Gene ID |
862 |
| Alternate Names |
- AML1T1protein CBFA2T1
- CBFA2T1Cyclin-D-related protein
- CDRMGC2796
- core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclinD-related
- DKFZp564B213
- Eight twenty one protein
- ETOFLJ33145
- MTG8acute myelogenous leukemia 1 translocation 1, cyclin-D related
- Protein ETO
- Protein MTG8
- runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- Zinc finger MYND domain-containing protein 2
- ZMYND2myeloid translocation gene on 8q22
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