Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Raptor (regulatory associated protein of TOR) is a conserved 150 kDa adaptor protein composed of a unique conserved region, three HEAT repeats and seven WD-40 repeats (1). Raptor recruits mTOR substrates S6K1 (p70 S6 kinase) and 4E-BP1, and regulates mTOR kinase activity (2-3). Even though Raptor is a positive regulator of mTOR, it has been shown that under nutrient deprivation, the Raptor-mTOR association is stabilized in a manner that inhibits mTOR kinase activity (1). Raptor association with mTOR is required for efficient S6K1 and 4E0BP1 phosphorylation (4).
Bioinformatics
| Product By Gene ID |
57521 |
| Alternate Names |
- KIAA1303
- KIAA1303p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
- KOG1
- Mip1
- p150 target of rapamycin (TOR)-scaffold protein
- Raptor
- regulatory associated protein of MTOR, complex 1
- regulatory-associated protein of mTOR
- RPTOR
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