RPTOR Products

Description

Raptor (regulatory associated protein of TOR) is a conserved 150 kDa adaptor protein composed of a unique conserved region, three HEAT repeats and seven WD-40 repeats (1). Raptor recruits mTOR substrates S6K1 (p70 S6 kinase) and 4E-BP1, and regulates mTOR kinase activity (2-3). Even though Raptor is a positive regulator of mTOR, it has been shown that under nutrient deprivation, the Raptor-mTOR association is stabilized in a manner that inhibits mTOR kinase activity (1). Raptor association with mTOR is required for efficient S6K1 and 4E0BP1 phosphorylation (4).

Bioinformatics

Entrez	287871 Rat 57521 Human 74370 Mouse
Uniprot	AAH64515 Human AAH64515.1 Human NP_065812 Human NP_065812.1 Human Q8N122 Human
Product By Gene ID	57521
Alternate Names	KIAA1303p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats KOG1 Mip1 p150 target of rapamycin (TOR)-scaffold protein raptor Raptor RAPTOR regulatory associated protein of MTOR, complex 1 regulatory-associated protein of mTOR

Research Areas for RPTOR

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Hypoxia
mTOR Pathway
Phospho-Specific
Signal Transduction