RP105/CD180 Products

Description

CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.

Bioinformatics

Entrez	17079 Mouse 4064 Human
Uniprot	BAA12019 Human P07948 Human Q99467 Human
Product By Gene ID	4064
Alternate Names	CD180 antigenMGC126233 CD180 molecule LY64MGC126234 Ly78 Lymphocyte antigen 64 lymphocyte antigen-64, radioprotective, 105kDa Radioprotective 105 kDa protein RP105lymphocyte antigen 64 (mouse) homolog, radioprotective, 105kD

Research Areas for RP105/CD180

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Innate Immunity