RP105/CD180 Products

Description

RP105 (CD180) is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD1 and form the cell surface receptor complex, RP105/MD1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. RP105 is a type I transmembrane protein of 105 KDa with extracellular leucine rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to drosophila Toll in the extracellular LLRs. RP105 is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody mediated (RP/14) cross-linking of RP105 induces resistance against irradiation induced apoptosis, B cell proliferation and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B cell activation. RP105 has an important role in B cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B cell surface expression and LPS recognition and signalling. MD1 seems to be requisite for efficient expression of RP105.

Bioinformatics

Product By Gene ID	4064
Alternate Names	CD180 antigenMGC126233 CD180 molecule CD180 Ly64 LY64MGC126234 Ly78 Lymphocyte antigen 64 lymphocyte antigen-64, radioprotective, 105kDa Radioprotective 105 kDa protein RP105 RP105lymphocyte antigen 64 (mouse) homolog, radioprotective, 105kD

Research Areas for RP105/CD180

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Innate Immunity