RelA/NFkB p65 Products

Description

Nuclear factor B (NF-B) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes. The family members include p50, p52, p65 (RelA), c-Rel, and RelB. The Nf-kB p65 subunit, similar to two others in the B family, RelB and c-Rel, contains two transactivation domains in the C-terminal region of the protein. Association with inhibitory proteins of the I B family, retains NF- B in the cytoplasm. Degradation of IB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-B to DNA. In addition to the nuclear translocation and DNA binding, Nf-kB's transcriptional activity is also regulated by coactivators and corepressors in the nucleus. Interaction of p65 with coactivators; CREB-binding protein and p300, increases its transcriptional activity.

Bioinformatics

Uniprot	AAH11603 Human AAH11603.1 Human AAH33522 Human CAA80524 Human NM_021975 Human NP_068810 Human Q04206 Human Q04207 Mouse Q99496 Human
Product By Gene ID	5970
Alternate Names	MGC131774 nf kb p65 NFkB p65 NF-kB p65 NFKB3v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor ofkappa light polypeptide gene enhancer in B-cells 3 (p65)) Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3transcription factor p65 p65 rela p65 RelA v-rel reticuloendotheliosis viral oncogene homolog A (avian) v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappalight polypeptide gene enhancer in B-cells 3, p65

Research Areas for RelA/NFkB p65

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Immune System Diseases
Immunology
Innate Immunity
Neurodegeneration
Neuroscience
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related RelA/NFkB p65 Blog Posts

Check out the latest blog posts on RelA/NFkB p65.

The effect of antioxidants and the NFkB p65 pathway in inflammation NFkB is a transcription factor that plays a role in the expression of genes involved in immune response, inflammation, metastasis, cell survival and more. RelA (p65) is one member of the NFkB mammalian family, alongside other subunits. NFkB subunit...    Read more.

NFkB3-p65: Say that three times fast! NF-kappa-B is a ubiquitous transcription factor involved in several biological processes such as inflammation, immunity, differentiation, cell growth, tumor genesis and apoptosis. Unlike the majority of transcription factors that reside in the nucleus...    Read more.

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1 By Jamshed Arslan Pharm.D. The cell’s oxygen-sensing machinery comprises prolyl-4-hydroxylases (P4Hs 1-3, PHDs 1-3, or EGLN 1-3) and their canonical target hypoxia-inducible factors (HIFs). When oxygen levels ...    Read more.

Read more RelA/NFkB p65 related blogs.