RB1 Products

Description

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of ts function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Bioinformatics

Entrez	19645 Mouse 24708 Rat 5925 Human
Uniprot	AAH40540 Human ABM85678.1 Human NP_000312 Human P06400 Human
Product By Gene ID	5925
Alternate Names	OSRC osteosarcoma p105-Rb pp110 pRb Rb RB retinoblastoma 1 retinoblastoma suspectibility protein retinoblastoma-associated protein

Research Areas for RB1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Phospho-Specific
Transcription Factors and Regulators
Tumor Suppressors