RASGRF1 Products

Antibodies
RASGRF1 Antibody
RASGRF1 Antibody
NBP1-85727
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
RASGRF1 Antibody
RASGRF1 Antibody
27320002
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
RASGRF1 Antibody
RASGRF1 Antibody
NBP1-19487
Species: Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
RASGRF1 Partial Recombinant P ...
RASGRF1 Partial Recombinant Protein
H00005923-Q01
Species: Hu
Applications: WB, ELISA, PA
RASGRF1 Recombinant Protein A ...
RASGRF1 Recombinant Protein Antigen
NBP1-85727PEP
Species: Hu
Applications: AC

Description

RASGRF1 is a critical step in signal transduction responses to stimulation of cell surface receptors by their ligands involves the accumulation of Ras proteins in their active GTP-bound state. To reach their active GTP-bound state, Ras proteins must first release bound GDP, a rate limiting step mediated by a guanine nucleotide releasing factor (GRF). The mammalian Ras p21 GRF protein has been designated Ras-GRF1 p140. Ras-GRF1 accelerates release of GDP from H- and N-Ras p21 protein in vitro, but not from the related Ral A or Cdc42Hs GTP-binding proteins. Of interest, a region mapping within the amino terminal domain of Ras-GRF1 is similar to both the human breakpoint cluster protein, Bcr, and the Dbl proto-oncogene product, a guanine nucleotide-releasing factor for Cdc42Hs. Ras-GRF2 p135 has also been identified. Ras-GRF2 p135 is highly homologous to Ras-GRF1 p140 except in the region between the REM and CDC25 domains and appears to function similarly to Ras-GRF1 p140.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 5923
Alternate Names
  • GRF1
  • Ras-GRF1
  • Guanine nucleotide-releasing protein
  • Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
  • PP13187
  • ras-specific guanine nucleotide-releasing factor 1
  • H-GRF55
  • ras-GRF1
  • GRF55
  • guanine nucleotide-releasing factor, 55 kD
  • CDC25L
  • GNRPguanine nucleotide-releasing factor 1
  • CDC25guanine nucleotide exchange factor
  • Ras-specific nucleotide exchange factor CDC25
  • Ras protein-specific guanine nucleotide-releasing factor 1

Research Areas for RASGRF1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

PTMs for RASGRF1

Learn more about PTMs related to RASGRF1.

Methylation
Phosphorylation
Demethylation
Farnesylation
Cleavage
Geranylgeranylation

Bioinformatics Tool for RASGRF1

Discover related pathways, diseases and genes to RASGRF1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.