RAR gamma/NR1B3 Products

Description

Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters. Retinoic acid receptor gamma has been shown to be the most important retinoid receptor for regulation of retinoic acid turnover rate and retinoic acid induced growth inhibition. While RAR mRNA levels may be useful biomarkers for various diseases, RAR gamma expression is decreased in Barrett's tissues compared with normal tissue.

Bioinformatics

Entrez	5916 Human
Product By Gene ID	5916
Alternate Names	NR1B3 NR1B3RARC Nuclear receptor subfamily 1 group B member 3 RAR gamma RARC RARG RAR-gamma retinoic acid receptor gamma retinoic acid receptor, gamma

Research Areas for RAR gamma/NR1B3

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Cancer