Rab5b Products

Antibodies
Rab5b Antibody
Rab5b Antibody
NBP1-58938
Species: Hu, Ma
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Rab5b Recombinant Protein
Rab5b Recombinant Protein
NBP1-50930
Applications: PAGE

Description

Rab5b is a member of the Rab family of small (monomeric) G proteins. Like other small G proteins, Rab5b switches between an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors (GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form, while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2, the defective gene at the PARK8 locus that results in Parkinson's disease. Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic plasticity have been suggested.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 5869
Alternate Names
  • ras-related protein Rab-5B
  • RAB5B, member RAS oncogene family

Research Areas for Rab5b

Find related products by research area and learn more about each of the different research areas below.

Endosome Markers
Signal Transduction

PTMs for Rab5b

Learn more about PTMs related to Rab5b.

Phosphorylation
Prenylation
Geranylgeranylation
Reduction

Bioinformatics Tool for Rab5b

Discover related pathways, diseases and genes to Rab5b. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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