PTP1B/PTPN1 Products

Description

The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme. Increased phosphorylation of PTP1B is seen to accompany the transition from G2 to M phase of the cell cycle. Immunofluorescence experiments indicate that PTP-1B is localized predominantly in the endoplasmic reticulum (ER). Subcellular fractionation is consistent with this localization and establishes that PTP-1B is tightly associated with microsomal membranes, with its phosphatase domain oriented towards the cytoplasm. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation (2). It has also been shown that PTP1B is a novel substrate for Akt and that phosphorylation of PTP1B by Akt at Ser(50) may negatively modulate its phosphatase activity creating a positive feedback mechanism for insulin signaling (3).

Bioinformatics

Entrez	19246 Mouse 24697 Rat 5770 Human
Uniprot	NM_002827 Human NP_002818 Human NP_002818.1 Human P18031 Human
Product By Gene ID	5770
Alternate Names	EC 3.1.3.48 protein tyrosine phosphatase 1B protein tyrosine phosphatase, non-receptor type 1 Protein-tyrosine phosphatase 1B PTP-1B PTP1Bprotein tyrosine phosphatase, placental tyrosine-protein phosphatase non-receptor type 1

Research Areas for PTP1B/PTPN1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific