PTP1B/PTPN1 Products

Antibodies
PTP1B/PTPN1 Antibody [Unconju ...
PTP1B/PTPN1 Antibody [Unconjugated]
AF1366
Species: Hu
Applications: WB, Simple Western, IHC
Host: Rabbit Polyclonal
PTP1B/PTPN1 Antibody (1D10)
PTP1B/PTPN1 Antibody (1D10)
NBP2-01056
Species: Hu, Ca, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
PTP1B/PTPN1 Antibody
PTP1B/PTPN1 Antibody
NBP1-28691
Species: Hu, Rt
Applications: IP, WB (-)
Host: Rabbit Polyclonal
Antibody Pairs
PTP1B/PTPN1 Antibody Pair
PTP1B/PTPN1 Antibody Pair
H00005770-PW1
Species: Hu
Applications: WB, IP
Lysates
PTP1B/PTPN1 Overexpression Ly ...
PTP1B/PTPN1 Overexpression Lysate ...
H00005770-T01
Species: Hu
Applications: WB
PTP1B/PTPN1 Overexpression Ly ...
PTP1B/PTPN1 Overexpression Lysate ...
NBL1-14967
Applications: WB
Proteins
Recombinant Human PTP1B/PTPN1 ...
Recombinant Human PTP1B/PTPN1 Protein
NBC1-18381
Species: Hu
Applications: Func, PAGE
PTP1B/PTPN1 Recombinant Prote ...
PTP1B/PTPN1 Recombinant Protein An...
NBP1-87191PEP
Species: Hu
Applications: AC
RNAi
PTP1B/PTPN1 RNAi
PTP1B/PTPN1 RNAi
H00005770-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme. Increased phosphorylation of PTP1B is seen to accompany the transition from G2 to M phase of the cell cycle. Immunofluorescence experiments indicate that PTP-1B is localized predominantly in the endoplasmic reticulum (ER). Subcellular fractionation is consistent with this localization and establishes that PTP-1B is tightly associated with microsomal membranes, with its phosphatase domain oriented towards the cytoplasm. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation (2). It has also been shown that PTP1B is a novel substrate for Akt and that phosphorylation of PTP1B by Akt at Ser(50) may negatively modulate its phosphatase activity creating a positive feedback mechanism for insulin signaling (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 5770
Alternate Names
  • PTP-1B
  • EC 3.1.3.48
  • tyrosine-protein phosphatase non-receptor type 1
  • Protein-tyrosine phosphatase 1B
  • PTP1Bprotein tyrosine phosphatase, placental
  • protein tyrosine phosphatase 1B
  • protein tyrosine phosphatase, non-receptor type 1

Research Areas for PTP1B/PTPN1

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Phospho-Specific

Bioinformatics Tool for PTP1B/PTPN1

Discover related pathways, diseases and genes to PTP1B/PTPN1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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