PSD-95 Products

Antibodies
PSD-95 Antibody (7E3)
PSD-95 Antibody (7E3)
NBP2-12872
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
PSD-95 Antibody [Unconjugated ...
PSD-95 Antibody [Unconjugated]
PPS059
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
PSD-95 Overexpression Lysate ...
PSD-95 Overexpression Lysate (Dena...
H00001742-T01
Species: Hu
Applications: WB
PSD-95 Overexpression Lysate ...
PSD-95 Overexpression Lysate (Native)
NBL1-09911
Applications: WB
Proteins
PSD-95 Recombinant Protein
PSD-95 Recombinant Protein
H00001742-P01
Species: Hu
Applications: WB, ELISA, In vitro, IP, PA
PSD-95 Partial Recombinant Pr ...
PSD-95 Partial Recombinant Protein
H00001742-Q01
Species: Hu
Applications: WB, ELISA, PA
PSD-95 Recombinant Protein An ...
PSD-95 Recombinant Protein Antigen
NBP1-80875PEP
Species: Hu
Applications: AC
RNAi
PSD-95 RNAi
PSD-95 RNAi
H00001742-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

Bioinformatics

Entrez Human
Mouse
Rat
Rat
Uniprot Human
Human
Human
Human
Rat
Product By Gene ID 1742
Alternate Names
  • FLJ97752
  • Tax interaction protein 15
  • Synapse-associated protein 90
  • post-synaptic density protein 95
  • Postsynaptic density protein 95
  • disks large homolog 4
  • PSD-95
  • PSD95SAP90SAP-90discs large homolog 4
  • FLJ98574
  • discs, large homolog 4 (Drosophila)

Research Areas for PSD-95

Find related products by research area and learn more about each of the different research areas below.

Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific

Bioinformatics Tool for PSD-95

Discover related pathways, diseases and genes to PSD-95. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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