Prothrombin Products

Description

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which mediate a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Proteolytic cleavage of Prothrombin (Factor II) at residue 44 leads to formation of Thrombin in the first step of the coagulation cascade. Thrombin cleaves bonds between Arg and Gly and activates Factors V, VII, VIII and XIII in complex with thrombomodulin and Protein C. Thrombin maintains vascular integrity during development and postnatal life and coordinates connective tissue proteins by stimulating fibroblast procollagen production.

Bioinformatics

Entrez	14061 Mouse 2147 Human 21834 Mouse 24831 Rat 29251 Rat
Uniprot	AAH51332 Human NM_000506 Human NP_000497 Human NP_000497.1 Human P00734 Human P18292 Rat P19221 Mouse
Product By Gene ID	2147
Alternate Names	coagulation factor II (thrombin) Coagulation factor II EC 3.4.21 EC 3.4.21.5 prothrombin B-chain prothrombin PT serine protease

Research Areas for Prothrombin

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer

Related Prothrombin Blog Posts

Check out the latest blog posts on Prothrombin.

Factor VIII - a key factor in the clotting process Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation...    Read more.

Read more Prothrombin related blogs.