Protein Kinase A regulatory subunit I alpha Products

Antibodies
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
Species: Hu, Mk
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
NBP2-33585
Species: Hu, Mouse, Rat
Applications: WB, Simple Western, IHC, IHC-P
Host: Rabbit Polyclonal
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
29250002
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-T01
Species: Hu
Applications: WB
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
NBP2-04233
Applications: WB
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
NBP2-04485
Applications: WB
Proteins
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-Q01
Species: Hu
Applications: WB, ELISA, PA
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-P01
Species: Hu
Applications: WB, ELISA, PA
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
NBP2-33585PEP
Species: Hu
Applications: AC
RNAi
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-R01
Species: Hu
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-R03
Species: Hu
Protein Kinase A regulatory s ...
Protein Kinase A regulatory subuni...
H00005573-R02
Species: Hu

Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5573
Alternate Names
  • PPNAD1
  • protein kinase A type 1a regulatory subunit
  • CNC1
  • cAMP-dependent protein kinase type I-alpha regulatory subunit
  • CAR
  • cAMP-dependent protein kinase type I-alpha regulatory chain
  • PRKAR1
  • cAMP-dependent protein kinase regulatory subunit RIalpha
  • PKR1
  • MGC17251
  • Tissue-specific extinguisher 1
  • TSE1DKFZp779L0468
  • CNC
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specificextinguisher 1)

Research Areas for Protein Kinase A regulatory subunit I alpha

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Cancer

PTMs for Protein Kinase A regulatory subunit I alpha

Learn more about PTMs related to Protein Kinase A regulatory subunit I alpha.

Phosphorylation
Cleavage
Methylation
Acetylation
Ribosylation
Myristoylation

Bioinformatics Tool for Protein Kinase A regulatory subunit I alpha

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