Species: Hu, Mu, Rt, Ca, Pm, Pm
Applications: WB, Flow
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: Binding Activity
Description
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. (provided by RefSeq)
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human Human |
Product By Gene ID |
5709 |
Alternate Names |
- 26S proteasome regulatory subunit RPN3
- 26S proteasome regulatory subunit S3
- P58
- proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
- Proteasome subunit p58
- RPN3
- Rpn3
- S3, 26S proteasome non-ATPase regulatory subunit 3
- tissue specific transplantation antigen 2
- TSTA2
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Bioinformatics Tool for Proteasome 19S S3
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