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1167-PR) inhibits Recombinant Human Prolactin (Catalog # 682-PL) induced proliferation in the Nb2-11 rat lymphoma cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human Prolactin (0.5 ng/mL) activity elicited by Recombinant Human Prolactin R Fc Chimera (5 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Prolactin R Monoclonal Antibody (Catalog # MAB1167). The ND50 is typically 2.5-9 µg/mL." class="big_lightbox" target="_blank">
HAF017). A specific band was detected for Prolactin R at approximately 95 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
![Western Blot Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Prolactin_R_AF1167_Western_Blot_20153.jpg)
![Sandwich ELISA Prolactin R Antibody Pair [HRP]](http://images.novusbio.com/fullsize/Prolactin-R-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79554-img0001.jpg)
![Immunohistochemistry Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1167_human-prolactin-r-affinity-purified-polyclonal-ab-8220249504629.jpg)
![Immunohistochemistry Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1167_human-prolactin-r-affinity-purified-polyclonal-ab-8220249511445.jpg)
![Immunohistochemistry Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1167_human-prolactin-r-affinity-purified-polyclonal-ab-8220249503244.jpg)
![Immunohistochemistry Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1167_human-prolactin-r-affinity-purified-polyclonal-ab-8220249505932.jpg)
![Immunohistochemistry Prolactin R Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1167_human-prolactin-r-affinity-purified-polyclonal-ab-4420241542502.jpg)
