PREB Products

Antibodies
PREB Antibody
PREB Antibody
NBP1-87056
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PREB Antibody
PREB Antibody
AF5557
Species: Hu
Applications: WB
Host: Goat Polyclonal
PREB Antibody
PREB Antibody
NBP1-87057
Species: Hu, Mu, Rt, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
PREB Overexpression Lysate (N ...
PREB Overexpression Lysate (Native)
NBL1-14744
Applications: WB
Proteins
PREB Recombinant Protein
PREB Recombinant Protein
H00010113-P01
Species: Hu
Applications: WB, ELISA, PA
PREB Partial Recombinant Prot ...
PREB Partial Recombinant Protein
H00010113-Q01
Species: Hu
Applications: WB, ELISA, PA
PREB Recombinant Protein Anti ...
PREB Recombinant Protein Antigen
NBP1-87057PEP
Species: Hu
Applications: AC
RNAi
PREB RNAi
PREB RNAi
H00010113-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 10113
Alternate Names
  • prolactin regulatory element-binding protein
  • prolactin regulatory binding-element protein
  • MGC3467
  • SEC12Mammalian guanine nucleotide exchange factor mSec12
  • prolactin regulatory element binding

Pathways for PREB

View related products by pathway and learn more about each of the pathways below.

Secretion
Insulin Secretion
Glucose Homeostasis
Response To Camp
Cell Cycle
Cell Fate Determination
Mating
Rna Interference
Sexual Reproduction

Research Areas for PREB

Find related products by research area and learn more about each of the different research areas below.

Transcription Factors and Regulators

Bioinformatics Tool for PREB

Discover related pathways, diseases and genes to PREB. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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