PRCC Products

Description

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.

Bioinformatics

Entrez	5546 Human
Uniprot	AAH10450 Human NM_005973 Human NP_005964.3 Human Q92733 Human
Product By Gene ID	5546
Alternate Names	MGC17178 papillary renal cell carcinoma (translocation-associated) Papillary renal cell carcinoma translocation-associated gene protein proline-rich protein PRCC RCCP1MGC4723 TPRC