PPP2R1A Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

5518

Alternate Names

Medium tumor antigen-associated 61 kDa protein MGC786 PP2A subunit A isoform PR65-alpha PP2A subunit A isoform R1-alpha PP2AAALPHA PP2A-Aalpha PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alphaisoform protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform protein phosphatase 2, regulatory subunit A, alpha serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alphaisoform serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alphaisoform

Research Areas for PPP2R1A

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Protein Phosphatase