PP1 Inhibitor-2 Products

Description

Two inhibitors of protein phosphatase 1 (PP1) include the phosphatase inhibitor 1 (IPP-1) and phosphatase inhibitor 2 (IPP-2). IPP-2, also known as I-2, interacts with the catalytic subunit of PP1 to form the heterodimer PP1I. The PP1I complex is present in the cytosol of cells in a broad range of vertebrate and invertebrate species. Although the heterodimer itself is inactive, a reversible phosphorylation of IPP-2 at Thr 72 by glycogen-synthase-kinase (GSK3) initiates activation of the heterodimer complex in vitro. Phosphorylation of IPP-2 by casein kinase-II at Ser 86, Ser 120, and Ser 121 enhances the rate of phosphorylation by GSK3 at Thr 72 and effectively activates the heterodimer complex. Besides moderating PP1 activity, IPP-2 may play a role as a chaperone for the correct folding of PP1. The gene for human IPP-2 maps to chromosome 6 in the major histocompatiblity complex region.

Bioinformatics

Entrez	5504 Human
Uniprot	NM_006241 Human NP_006232 Human NP_006232.1 Human P41236 Human
Product By Gene ID	5504
Alternate Names	IPP-2 IPP2phosphatase inhibitor 2 MGC87148 phosphoprotein phosphatase protein phosphatase 1, regulatory (inhibitor) subunit 2 protein phosphatase inhibitor 2

Research Areas for PP1 Inhibitor-2

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Protein Phosphatase