PP1 Inhibitor-2 Products

Antibodies
PP1 Inhibitor-2 Antibody [Unc ...
PP1 Inhibitor-2 Antibody [Unconjug...
AF4719
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Goat Polyclonal
PP1 Inhibitor-2 Antibody (488 ...
PP1 Inhibitor-2 Antibody (488123)
MAB4719
Species: Hu
Applications: WB
Host: Mouse Monoclonal
PP1 Inhibitor-2 Antibody
PP1 Inhibitor-2 Antibody
NBP2-48801
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
PP1 Inhibitor-2 Antibody Pair ...
PP1 Inhibitor-2 Antibody Pair
H00005504-AP11
Species: Hu
Applications: S-ELISA
Lysates
PP1 Inhibitor-2 Overexpressio ...
PP1 Inhibitor-2 Overexpression Lys...
NBL1-14682
Species: Hu
Applications: WB
PP1 Inhibitor-2 Overexpressio ...
PP1 Inhibitor-2 Overexpression Lys...
H00005504-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human PP1 Inhibit ...
Recombinant Human PP1 Inhibitor-2 ...
H00005504-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human PP1 Inhibit ...
Recombinant Human PP1 Inhibitor-2 ...
H00005504-P01
Species: Hu
Applications: WB, ELISA, PA
PP1 Inhibitor-2 Recombinant P ...
PP1 Inhibitor-2 Recombinant Protei...
NBP2-48801PEP
Species: Hu
Applications: AC
RNAi
PP1 Inhibitor-2 RNAi
PP1 Inhibitor-2 RNAi
H00005504-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Two inhibitors of protein phosphatase 1 (PP1) include the phosphatase inhibitor 1 (IPP-1) and phosphatase inhibitor 2 (IPP-2). IPP-2, also known as I-2, interacts with the catalytic subunit of PP1 to form the heterodimer PP1I. The PP1I complex is present in the cytosol of cells in a broad range of vertebrate and invertebrate species. Although the heterodimer itself is inactive, a reversible phosphorylation of IPP-2 at Thr 72 by glycogen-synthase-kinase (GSK3) initiates activation of the heterodimer complex in vitro. Phosphorylation of IPP-2 by casein kinase-II at Ser 86, Ser 120, and Ser 121 enhances the rate of phosphorylation by GSK3 at Thr 72 and effectively activates the heterodimer complex. Besides moderating PP1 activity, IPP-2 may play a role as a chaperone for the correct folding of PP1. The gene for human IPP-2 maps to chromosome 6 in the major histocompatiblity complex region.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 5504
Alternate Names
  • protein phosphatase inhibitor 2
  • MGC87148
  • phosphoprotein phosphatase
  • IPP-2
  • IPP2phosphatase inhibitor 2
  • protein phosphatase 1, regulatory (inhibitor) subunit 2

Pathways for PP1 Inhibitor-2

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Metaphase
Meiosis
Localization

Research Areas for PP1 Inhibitor-2

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Protein Phosphatase

PTMs for PP1 Inhibitor-2

Learn more about PTMs related to PP1 Inhibitor-2.

Phosphorylation

Bioinformatics Tool for PP1 Inhibitor-2

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