POU3F2/OCT7 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene. The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo. Chimera RNAi has many advantages over the conventional siRNAs. First, it has been demonstrated to have reliable knock-down for over 10,000 human genes. Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence. Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected. Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	5454
Alternate Names	Brain-2 Brain-specific homeobox/POU domain protein 2 BRN2 brn-2 BRN2brain-2 Nervous system-specific octamer-binding transcription factor N-Oct-3 Oct7 oct-7 OCT7POU domain class 3, transcription factor 2 Octamer-binding protein 7 Octamer-binding transcription factor 7 OTF7 OTF-7 POU class 3 homeobox 2 POU domain, class 3, transcription factor 2 POU3F2 POUF3

Research Areas for POU3F2/OCT7

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Transcription Factors and Regulators

Related POU3F2/OCT7 Blog Posts

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Deriving neural precursor cells from human induced pluripotent stem cells By Jennifer Sokolowski, MD, PhD.Human induced pluripotent stem cells (iPSCs) can be used to create models of human organ systems and are useful for a) ascertaining the mechanisms underlying pathological conditions...    Read more.

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