POGZ Products

Description

Pogz is a zinc-finger protein containing at least 8 C2H2 zinc fingers, a CENP-B (centromere protein-B) domain, and a DDE domain found in the bacterial transposase/retroviral integrase family. Members of this family of integrases share structural homologies and show similar catalytic activity to the RAG1 and RAG2 proteins that initiate V(D)J recombination in lymphoid progenitors. Mouse Pogz has a human homolog with a base pair similarity of 90% and amino acid similarity of 93% for the full length protein. In humans at least 3 variants have been predicted and they are all similar at the Nterminus. A number of expressed sequence tags (ESTs) cloned from murine undifferentiated ES cells and Lin-/c-Kit+/Sca-1+ hematopoietic stem cell cDNA libraries correspond to the Pogz gene, further underlining an important function for this gene in stem cells. In mice, deletion of the gene in all tissues early in embryogenesis has been shown to be lethal.

Bioinformatics

Entrez	229584 Mouse 23126 Human 310658 Rat
Uniprot	NP_997054 Human NP_997054.1 Human Q7Z3K3 Human
Product By Gene ID	23126
Alternate Names	KIAA0461ZNF635 pogo transposable element with ZNF domain putative protein product of Nbla00003 SUHW5MGC71543 Suppressor of hairy wing homolog 5 Zinc finger protein 280E Zinc finger protein 635 ZNF280EZNF635m