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HAF008). A specific band was detected for PILR-a at approximately 35-50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
F0111). Quadrant markers were set based on control antibody staining (Catalog # MAB1050). View our protocol for Staining Intracellular Molecules." class="big_lightbox" target="_blank">
VC003). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to dendritic cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
Species: Hu Applications: WB, Flow, IHC Host: Rabbit Monoclonal
AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107)." class="big_lightbox" target="_blank">
CP004) at 2.00 μg/mL (100 μL/well), Recombinant Human PANP Fc Chimera Protein (7920-PN) binds with an ED50 of 8.00-80.0 ng/mL." class="big_lightbox" target="_blank">
7920-PN) is coated at 5 μg/mL, 100 uL/well, Biotinylated Recombinant Human PILR‑ alpha Fc Chimera Avi-tag (Catalog # AVI10702) binds with an ED50 of 0.6-6 μg/mL." class="big_lightbox" target="_blank">
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. (provided by RefSeq)
![Western Blot PILR-alpha Antibody (2175D) [Unconjugated]](http://images.novusbio.com/images/antibody/PILRalpha_MAB64841_Western_Blot_21242.jpg)
![Binding Activity PILR-alpha [Biotin]](http://images.novusbio.com/images/avi10702_recombinant-human-pilr-alpha-fc-chimera-avi-tag-protein-cf-binding-activity-293202111246.jpg)
![SDS-Page PILR-alpha [Unconjugated]](http://images.novusbio.com/fullsize/10802-pr_recombinant-human-pilr-alpha-fc-chimera-protein-cf-sds-page-236202110714.jpg)
![Flow Cytometry PILR-alpha Antibody (2175D) [Unconjugated]](http://images.novusbio.com/images/antibody/PILRalpha_MAB64841_Flow_Cytometry_21219.jpg)
![Immunohistochemistry PILR-alpha Antibody (2175D) [Unconjugated]](http://images.novusbio.com/images/antibody/PILRalpha_MAB64841_Immunohistochemistry_21149.jpg)
![Flow Cytometry PILR-alpha Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PILR-alpha_AF4318_Flow_Cytometry_10883.jpg)
![Binding Activity PILR-alpha [Biotin]](http://images.novusbio.com/images/avi6484_recombinant-human-pilr-alpha-avi-tag-his-tag-protein-cf-binding-activity-298202214012.jpg)
![SDS-Page PILR-alpha [Biotin]](http://images.novusbio.com/fullsize/avi6484_recombinant-human-pilr-alpha-avi-tag-his-tag-protein-cf-sds-page-2872022112147.jpg)
