PILR-alpha Products

Description

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. (provided by RefSeq)

Bioinformatics

Entrez	29992 Human
Uniprot	AAH17812 Human NP_840057 Human Q9UKJ1-4 Human
Product By Gene ID	29992
Alternate Names	Cell surface receptor FDF03 FDF03 inhibitory receptor PILRalpha Inhibitory receptor PILR-alpha paired immunoglobin-like receptor alpha paired immunoglobin-like type 2 receptor alpha paired immunoglobulin-like receptor alpha paired immunoglobulin-like type 2 receptor alpha

Research Areas for PILR-alpha

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Signal Transduction