PIGA Products

Antibodies
PIGA Antibody
PIGA Antibody
NBP2-13760
Species: Hu, Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
PIGA Antibody
PIGA Antibody
NBP1-59701
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
PIGA Antibody
PIGA Antibody
NBP2-19827
Species: Mu
Applications: WB
Host: Rabbit Polyclonal
Proteins
Recombinant Human PIGA Protei ...
Recombinant Human PIGA Protein
H00005277-Q01
Species: Hu
Applications: WB, ELISA, PA
PIGA Recombinant Protein Anti ...
PIGA Recombinant Protein Antigen
NBP2-13760PEP
Species: Hu
Applications: AC

Description

PIGA, also known as Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, has three isoforms that are produced by alternative splicing. Isoform 1, the canonical sequence, is 484 amino acids long and 54 kDa. Isoform 2 and 3 are both shorter isoforms, at 315 and 250 amino acids, respectively. PIGA is a critical player in the synthesis of N-acetylglucosaminyl-phosphatidylinositol, which is the first intermediate in the biosynthesis of GPI anchors. Current research on PIGA is being conducted in relation to several diseases and disorders including Paroxysmal nocturnal hemoglobinuria, which may be caused by mutations in the PIGA gene. Other diseases and disorders related to PIGA include multiple congenital anomalies-hypotonia-seizures syndrome type 2, anemia, Burkitt's lymphoma, hepatic vein thrombosis and Myelodysplastic syndrome. PIGA has been shown to have interactions with DPM2, PIGQ, PIGH, PYURF and PIGP in pathways such as GPI anchor biosynthesis and metabolic pathways.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 5277
Alternate Names
  • phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria)
  • Phosphatidylinositol-glycan biosynthesis class A protein
  • EC 2.4.1.198
  • phosphatidylinositol-glycan biosynthesis, class A protein
  • PIG-A
  • phosphatidylinositol N-acetylglucosaminyltransferase subunit A
  • GlcNAc-PI synthesis protein
  • GPI anchor biosynthesis
  • GPI3
  • class A GlcNAc-inositol phospholipid assembly protein
  • phosphatidylinositol glycan anchor biosynthesis, class A

PTMs for PIGA

Learn more about PTMs related to PIGA.

Gpi Anchoring
Phosphorylation
Cleavage
Methylation

Bioinformatics Tool for PIGA

Discover related pathways, diseases and genes to PIGA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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