Host: Sheep Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA, AP
Piccolo is a presynaptic cytomatrix protein concentrated at the presynaptic side of synaptic junctions. Piccolo is a large protein which constists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains (PBH-domains) and C-terminal PDZ and C2 domains. It is usually found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Recently piccolo has been shown to interfere with clathrin mediated endocytosis by binding to the F-actin and dynamin binding protein Abp1. Piccolo is highly expressed in brain with low levels found in stomach. It is not detected in other tissues analyzed including adrenal gland, testis and pancreas.
Bioinformatics Tool for Piccolo
Discover related pathways, diseases and genes to Piccolo. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.