PEA-15 Products

Antibodies
PEA-15 Antibody
PEA-15 Antibody
AF5588
Species: Hu, Mu
Applications: WB, IHC
Host: Sheep Polyclonal
PEA-15 Antibody
PEA-15 Antibody
NB100-92204
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PEA-15 Antibody
PEA-15 Antibody
NB100-92352
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
PEA-15 Overexpression Lysate ...
PEA-15 Overexpression Lysate (Native)
NBL1-14273
Applications: WB
Proteins
PEA-15 Recombinant Protein
PEA-15 Recombinant Protein
NBP1-30247
Species: Hu
Applications: PAGE
RNAi
PEA-15 RNAi
PEA-15 RNAi
H00008682-R01
Species: Hu

Description

PEA-15 (phosphoprotein enriched in astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 co-localizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, phosphoprotein enriched in diabetes, for its elevated expression in type 2 diabetic patients.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 8682
Alternate Names
  • PEA-15
  • HMAT115kD
  • PED15 kDa phosphoprotein enriched in astrocytes
  • Phosphoprotein enriched in diabetes
  • phosphoprotein enriched in astrocytes 15

Research Areas for PEA-15

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cytoskeleton Markers
Phospho-Specific

Bioinformatics Tool for PEA-15

Discover related pathways, diseases and genes to PEA-15. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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