PCM1 Products

Antibodies
PCM1 Antibody
PCM1 Antibody
NBP1-87196
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PCM1 Antibody
PCM1 Antibody
NBP1-87195
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PCM1 Antibody (CL0206)
PCM1 Antibody (CL0206)
NBP2-52878
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
PCM1 Overexpression Lysate (D ...
PCM1 Overexpression Lysate (Denatu...
H00005108-T01
Species: Hu
Applications: WB
Proteins
PCM1 Recombinant Protein
PCM1 Recombinant Protein
H00005108-P01
Species: Hu
Applications: WB, ELISA, PA
PCM1 Recombinant Protein Anti ...
PCM1 Recombinant Protein Antigen
NBP2-52878PEP
Species: Hu
Applications: AC
PCM1 Recombinant Protein Anti ...
PCM1 Recombinant Protein Antigen
NBP1-87196PEP
Species: Hu
Applications: AC
RNAi
PCM1 RNAi
PCM1 RNAi
H00005108-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 5108
Alternate Names
  • pericentriolar material 1 protein
  • hPCM-1
  • PTC4PCM-1
  • pericentriolar material 1

Research Areas for PCM1

Find related products by research area and learn more about each of the different research areas below.

Mitotic Regulators

PTMs for PCM1

Learn more about PTMs related to PCM1.

Phosphorylation
Methylation
Ubiquitination

Bioinformatics Tool for PCM1

Discover related pathways, diseases and genes to PCM1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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