PAK4 Products

Description

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Bioinformatics

Entrez	10298 Human
Uniprot	AAH02921 Human
Product By Gene ID	10298
Alternate Names	EC 2.7.11 EC 2.7.11.1 KIAA1142 p21 protein (Cdc42/Rac)-activated kinase 4 p21(CDKN1A)-activated kinase 4 p21-activated kinase 4 PAK4 PAK-4 protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs serine/threonine-protein kinase PAK 4

Research Areas for PAK4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Protein Kinase