PAG3 Products

Antibodies
PAG3 Antibody
PAG3 Antibody
NBP2-24614
Species: Hu, Mu, Rt, Op, Pm
Applications: WB
Host: Rabbit Polyclonal
PAG3 Antibody
PAG3 Antibody
NBP2-19678
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
PAG3 Antibody
PAG3 Antibody
NBP1-78214
Species: Hu, Equine, Primate
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
PAG3 Overexpression Lysate (D ...
PAG3 Overexpression Lysate (Denatu...
H00008853-T01
Species: Hu
Applications: WB
Proteins
PAG3 Partial Recombinant Prot ...
PAG3 Partial Recombinant Protein
H00008853-Q01
Species: Hu
Applications: WB, ELISA, PA
PAG3 Recombinant Protein
PAG3 Recombinant Protein
H00008853-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
PAG3 RNAi
PAG3 RNAi
H00008853-R01
Species: Hu

Description

PAG3 encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 8853
Alternate Names
  • Paxillin-associated protein with ARF GAP activity 3
  • PYK2 C terminus-associated protein
  • Development and differentiation-enhancing factor 2
  • centaurin, beta 3
  • development and differentiation enhancing factor 2
  • arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
  • SHAG1
  • Pap-alpha
  • CENTB3
  • DDEF2FLJ42910
  • KIAA0400AMAP2
  • PAPPAG3
  • Pyk2 C-terminus-associated protein
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Research Areas for PAG3

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Cellular Markers
Cytoskeleton Markers
Phospho-Specific

PTMs for PAG3

Learn more about PTMs related to PAG3.

Phosphorylation
Ribosylation

Bioinformatics Tool for PAG3

Discover related pathways, diseases and genes to PAG3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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