PA28 Activator alpha Subunit/PSME1 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.

Bioinformatics

Entrez	19186 Mouse 29630 Rat 5720 Human
Uniprot	AAH00352 Human NM_006263 Human NP_006254 Human NP_006254.1 Human Q06323 Human
Product By Gene ID	5720
Alternate Names	11S regulator complex alpha subunit 11S regulator complex subunit alpha 29-kD MCP activator subunit IFI5111MGC8628 IGUP I-5111 Interferon gamma up-regulated I-5111 protein interferon-gamma IEF SSP 5111 interferon-gamma-inducible protein 5111 PA28a PA28A PA28alphaActivator of multicatalytic protease subunit 1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Proteasome activator 28 subunit alpha proteasome activator complex subunit 1 proteasome activator subunit-1 REGalpha REG-alpha