PA28 Activator alpha Subunit/PSME1 Products

Antibodies
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
NBP1-83121
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
H00005720-D01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
H00005720-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Lysates
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
H00005720-T01
Species: Hu
Applications: WB
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
NBL1-14907
Applications: WB
Proteins
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
NBP1-83121PEP
Species: Hu
Applications: AC
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
NBP1-49437
Species: Hu
Applications: PAGE
RNAi
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
H00005720-R02
Species: Hu
PA28 Activator alpha Subunit/ ...
PA28 Activator alpha Subunit/PSME1...
H00005720-R01
Species: Hu

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5720
Alternate Names
  • PA28a
  • 11S regulator complex alpha subunit
  • proteasome activator subunit-1
  • IGUP I-5111
  • proteasome activator complex subunit 1
  • REG-alpha
  • interferon-gamma-inducible protein 5111
  • 11S regulator complex subunit alpha
  • interferon-gamma IEF SSP 5111
  • Proteasome activator 28 subunit alpha
  • REGalpha
  • Interferon gamma up-regulated I-5111 protein
  • PA28A
  • PA28alphaActivator of multicatalytic protease subunit 1
  • IFI5111MGC8628
  • 29-kD MCP activator subunit
  • proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

PTMs for PA28 Activator alpha Subunit/PSME1

Learn more about PTMs related to PA28 Activator alpha Subunit/PSME1.

Cleavage
Phosphorylation
Oxidation
Dephosphorylation
Ubiquitination

Bioinformatics Tool for PA28 Activator alpha Subunit/PSME1

Discover related pathways, diseases and genes to PA28 Activator alpha Subunit/PSME1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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