OGG1 Products

Antibodies
Antibody Pairs
OGG1 Antibody Pair
OGG1 Antibody Pair
H00004968-PW1
Species: Hu
Applications: WB, IP
Lysates
OGG1 Overexpression Lysate (D ...
OGG1 Overexpression Lysate (Denatu...
H00004968-T01
Species: Hu
Applications: WB
OGG1 Overexpression Lysate (N ...
OGG1 Overexpression Lysate (Native)
NBP2-09881
Applications: WB
OGG1 Overexpression Lysate (N ...
OGG1 Overexpression Lysate (Native)
NBP2-06990
Applications: WB
Proteins
OGG1 Peptide
OGG1 Peptide
NB100-106PEP
Species: Hu
OGG1 Recombinant Protein
OGG1 Recombinant Protein
NBP1-45318
Species: Hu
Applications: PAGE
RNAi
OGG1 RNAi
OGG1 RNAi
H00004968-R03
Species: Hu
OGG1 RNAi
OGG1 RNAi
H00004968-R08
Species: Hu
OGG1 RNAi
OGG1 RNAi
H00004968-R01
Species: Hu

Description

Ogg1 encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. 8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. Ogg1 proteins efficiently release the 8-hydroxyguanine opposite the pyrimidine from DNA and cleave the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The Ogg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer. Recent work has demonstrated that Ogg plays an important role in CAG expansion, a characteristic of several neurodegenerative diseases. Ogg appears to be responsible for progressive expansion of poly-Q tracts in response to oxidative damage. Thus, Ogg provides a direct link between DNA damage and toxicity in neurons.

Bioinformatics

Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 4968
Alternate Names
  • MMH
  • N-glycosylase/DNA lyase
  • 8-hydroxyguanine DNA glycosylase
  • DNA-apurinic or apyrimidinic site lyase
  • HOGG1
  • AP lyase
  • MUTMOGH1HMMH
  • 8-oxoguanine DNA glycosylase

Research Areas for OGG1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
DNA Repair

Bioinformatics Tool for OGG1

Discover related pathways, diseases and genes to OGG1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related OGG1 Blog Posts

Check out the latest blog posts on OGG1.
You down with Ogg? Yeah, you know me
8-hydroxyguanine is a form of oxidative DNA damage where free radicals cause G:C to T:A transversions within the backbone. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine mutations. One of these enzymes,...    Read more.
Read more OGG1 related blogs.