OGG1 Products

Description

Ogg1 encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. 8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. Ogg1 proteins efficiently release the 8-hydroxyguanine opposite the pyrimidine from DNA and cleave the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The Ogg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer. Recent work has demonstrated that Ogg plays an important role in CAG expansion, a characteristic of several neurodegenerative diseases. Ogg appears to be responsible for progressive expansion of poly-Q tracts in response to oxidative damage. Thus, Ogg provides a direct link between DNA damage and toxicity in neurons.

Bioinformatics

Uniprot	AAH00657 Human NP_058212.1 Human NP_058214 Human O08760 Mouse O15527 Human
Product By Gene ID	4968
Alternate Names	8-hydroxyguanine DNA glycosylase 8-oxoguanine DNA glycosylase AP lyase DNA-apurinic or apyrimidinic site lyase HOGG1 MMH MUTMOGH1HMMH N-glycosylase/DNA lyase

Research Areas for OGG1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
DNA Repair

Related OGG1 Blog Posts

Check out the latest blog posts on OGG1.

You down with Ogg? Yeah, you know me 8-hydroxyguanine is a form of oxidative DNA damage where free radicals cause G:C to T:A transversions within the backbone. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine mutations. One of these enzymes,...    Read more.

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