NXF5 Products

Description

NXF5, also known as Nuclear RNA export factor 5, consists of 6 isoforms ranging from a 168 amino acid isoform that is 20 kDa to a 397 amino acid isoform that is 46 kDa, it is implicated in mRNA nuclear export and could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. On the other hand, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Current research is being performed on several diseases including pelizaeus-merzbacher disease, premature ovarian failure, short stature, intellectual disability, influenza, and neuronitis. The NXF5 has shown an interaction with ALYREF, EIF4A3, NUP98, NUPL2, NXT1, NXT2, RAE1, and THOC5 in ribosome biogenesis in eukaryotes, RNA transport, mRNA surveillance pathway, and influenza A pathways.

Bioinformatics

Uniprot	Q9H1B4 Human NP_116564 Human
Product By Gene ID	55998
Alternate Names	TAPL1 TAP-like protein 1 TAPL-1 nuclear RNA export factor 5

Diseases related to NXF5

Discover more about diseases related to NXF5.

Dwarfism
Amenorrhea
Premature Menopause
Turner Syndrome
Severe Mental Retardation
Chromosome Inversion
Muscle Hypotonia
Ovarian Failure, Premature
Brachycephaly
Pelizaeus-merzbacher Disease
Personality Disorders
Infertility
X Chromosome, Trisomy Xq
Primary Physiologic Amenorrhea
Congenital Anomaly Of Face
Neoplasms
Scoliosis, Unspecified
Chromosome Breakage

Pathways for NXF5

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Nuclear Export
Transport
Methylation
Dna Hypomethylation
Dna Methylation
Pathogenesis
Mrna Transport

PTMs for NXF5

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Methylation

Bioinformatics Tool for NXF5

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