nSMase Products

Antibodies
nSMase Antibody
nSMase Antibody
NBP1-87810
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
nSMase Antibody (2C9)
nSMase Antibody (2C9)
H00006610-M01
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
nSMase Antibody
nSMase Antibody
NBP1-59937
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
nSMase Overexpression Lysate ...
nSMase Overexpression Lysate (Native)
NBP2-10865
Applications: WB
Proteins
nSMase Recombinant Protein
nSMase Recombinant Protein
H00006610-P01
Species: Hu
Applications: WB, ELISA, PA
nSMase Recombinant Protein An ...
nSMase Recombinant Protein Antigen
NBP1-87810PEP
Species: Hu
Applications: AC
RNAi
nSMase RNAi
nSMase RNAi
H00006610-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Sphingomyelin is also present in all eukaryotic cell membranes, especially the plasma membrane, and is particularly concentrated in the nervous system because sphingomyelin is a major component of myelin, the fatty insulation wrapped around nerve cells by Schwann cells or oligodendrocytes. Multiple Sclerosis is a disease characterised by deterioration of the myelin sheath, leading to impairment of nervous conduction. nSMase (Neutral sphingomyelinase; Sphingomyelin phosphodiesterase 2) converts sphingomyelin to ceramide. Although widely expressed in all tissues examined, except the spleen, high enzymatic activity occurs only in the brain. Mice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 6610
Alternate Names
  • Lyso-PAF-PLC
  • N-SMase
  • EC 3.1.4.12
  • Neutral sphingomyelinase
  • sphingomyelin phosphodiesterase 2
  • Lyso-platelet-activating factor-phospholipase C
  • lyso-PAF-PLC
  • nSMase
  • NSMASE1
  • ISC1
  • NSMASE
  • sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

Diseases related to nSMase

Discover more about diseases related to nSMase.

Malignant Neoplasms
Neoplasms
Delayed Puberty
Pituitary Diseases
Dwarfism

Pathways for nSMase

View related products by pathway and learn more about each of the pathways below.

Secretory Pathway
Cell Death
Cell Growth

Research Areas for nSMase

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism

Bioinformatics Tool for nSMase

Discover related pathways, diseases and genes to nSMase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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