NRIP Products

Description

WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies. Their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up-regulates their transcriptional activity, thereby functioning as a nuclear receptor co-activator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer, thus indicating a potential therapeutic intervention. Northern Blot analysis detects a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.

Bioinformatics

Uniprot	AAX09330 Human NP_060912 Human Q58WW2 Human
Product By Gene ID	55827
Alternate Names	1200006M05Rik Androgen receptor complex-associated protein ARCAP DDB1 and CUL4 associated factor 6 DDB1- and CUL4-associated factor 6 FLJ23798 IQ motif and WD repeat-containing protein 1 IQ motif and WD repeats 1 IQWD1 MSTP055 NRIP Nuclear receptor interaction protein PC326