NOXO1 Products

Antibodies
NOXO1 Antibody
NOXO1 Antibody
NB300-950
Species: Hu
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
NOXO1 Antibody
NOXO1 Antibody
NBP1-77899
Species: Hu, Pm
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
NOXO1 Antibody
NOXO1 Antibody
NBP2-49663
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Lysates
NOXO1 Overexpression Lysate ( ...
NOXO1 Overexpression Lysate (Native)
NBL1-13735
Applications: WB
NOXO1 Overexpression Lysate ( ...
NOXO1 Overexpression Lysate (Native)
NBL1-13736
Applications: WB
Proteins
NOXO1 Partial Recombinant Pro ...
NOXO1 Partial Recombinant Protein
H00124056-Q01
Species: Hu
Applications: WB, ELISA, PA
NOXO1 Recombinant Protein Ant ...
NOXO1 Recombinant Protein Antigen
NBP2-49663PEP
Species: Hu
Applications: AC
RNAi
NOXO1 RNAi
NOXO1 RNAi
H00124056-R02
Species: Hu
NOXO1 RNAi
NOXO1 RNAi
H00124056-R01
Species: Hu
NOXO1 RNAi
NOXO1 RNAi
H00124056-R03
Species: Hu

Description

NOXO1 (Nox organizing protein 1) and NOXA1 (Nox Activating protein 1) are homologs of p47phox and p67phox. p47phox functions in phagocytes as an essential organizing protein mediating the binding of other regulatory proteins during activation of the phagocyte oxidase, and its translocation to the membrane is triggered upon cell activation by hyperphosphorylation, which relieves autoinhibition of SH3 and PX domains. NOXO1 lacks an auto inhibitory region and phosphorylation sites that are present in p47phox. Co-transfection of Nox1, NOXO1 and NOXA1 reconstitutes ROS (reactive oxygen species) generation in HEK 293 cells in the absence of cell stimulation. NOXO1 binds to the phosphatidylinositol (PtdIns) lipids PtdIns 3,5-P2, PtdIns 5-P and PtdIns 4-P. Unlike p47phox, which is located in the cytosol of resting cells and translocates to the plasma membrane where gp91phox is located, NOXO1 co-localizes with Nox1 in the membranes of resting cells. This localization of NOXO1 is dictated by its PX domain, since this domain but not the remainder of the molecule localizes to membranes.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 124056
Alternate Names
  • Nox-organizing protein 1
  • regulatory protein P41NOX
  • SNX28
  • MGC20258
  • P41NOXC
  • SH3 and PX domain-containing protein 5
  • P41NOXB
  • Nox organizer 1
  • P41NOXA
  • SH3PXD5NADPH oxidase regulatory protein
  • P41NOX
  • NADPH oxidase organizer 1

Research Areas for NOXO1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research
Immunology
Innate Immunity
Signal Transduction

PTMs for NOXO1

Learn more about PTMs related to NOXO1.

Phosphorylation
Glycosylation
Dephosphorylation

Bioinformatics Tool for NOXO1

Discover related pathways, diseases and genes to NOXO1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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