NOXO1 Products

Description

NOXO1 (Nox organizing protein 1) and NOXA1 (Nox Activating protein 1) are homologs of p47phox and p67phox. p47phox functions in phagocytes as an essential organizing protein mediating the binding of other regulatory proteins during activation of the phagocyte oxidase, and its translocation to the membrane is triggered upon cell activation by hyperphosphorylation, which relieves autoinhibition of SH3 and PX domains. NOXO1 lacks an auto inhibitory region and phosphorylation sites that are present in p47phox. Co-transfection of Nox1, NOXO1 and NOXA1 reconstitutes ROS (reactive oxygen species) generation in HEK 293 cells in the absence of cell stimulation. NOXO1 binds to the phosphatidylinositol (PtdIns) lipids PtdIns 3,5-P2, PtdIns 5-P and PtdIns 4-P. Unlike p47phox, which is located in the cytosol of resting cells and translocates to the plasma membrane where gp91phox is located, NOXO1 co-localizes with Nox1 in the membranes of resting cells. This localization of NOXO1 is dictated by its PX domain, since this domain but not the remainder of the molecule localizes to membranes.

Bioinformatics

Uniprot	AAH15917 Human NM_144603 Human NM_172167 Human NP_653204 Human NP_653204.1 Human Q8NFA2 Human
Product By Gene ID	124056
Alternate Names	MGC20258 NADPH oxidase organizer 1 Nox organizer 1 Nox-organizing protein 1 P41NOX P41NOXA P41NOXB P41NOXC regulatory protein P41NOX SH3 and PX domain-containing protein 5 SH3PXD5NADPH oxidase regulatory protein SNX28

Research Areas for NOXO1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research
Immunology
Innate Immunity
Signal Transduction