Notch-1 Products

Notch-1 Antibody - (Cleaved N ...
Notch-1 Antibody - (Cleaved N term...
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Human Notch-1 DuoSet ELISA, 1 ...
Human Notch-1 DuoSet ELISA, 15 Plate
Species: Hu
Applications: ELISA
Human Notch-1 ELISA Kit (Colo ...
Human Notch-1 ELISA Kit (Colorimet...
Species: Hu
Applications: ELISA, QFN
Notch-1 Overexpression Lysate ...
Notch-1 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human Notch-1 Fc ...
Recombinant Human Notch-1 Fc Chime...
Species: Hu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Rat Notch-1 Fc Ch ...
Recombinant Rat Notch-1 Fc Chimera...
Species: Rt
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Mouse Notch-1 Fc ...
Recombinant Mouse Notch-1 Fc Chime...
Species: Mu
Applications: Binding Activity
Formulation Catalog # Availability Price  


Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.


Uniprot Human
Product By Gene ID 4851
Alternate Names
  • EC
  • EC
  • hN1
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • notch 1Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • TAN1neurogenic locus notch homolog protein 1
  • Translocation-associated notch protein TAN-1

Research Areas for Notch-1

Find related products by research area and learn more about each of the different research areas below.

Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Signal Transduction
Stem Cell Signaling Pathway

Bioinformatics Tool for Notch-1

Discover related pathways, diseases and genes to Notch-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related Notch-1 Blog Posts

Check out the latest blog posts on Notch-1.
Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...    Read more.
Read more Notch-1 related blogs.