Species: Hu, Mu, Rt(-)
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, CyTOF-ready, KO
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA, QFN
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Rt
Applications: Binding Activity
Species: Mu
Applications: Binding Activity
Description
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.
Bioinformatics
Uniprot |
Human Human Human Human Mouse |
Product By Gene ID |
4851 |
Alternate Names |
- EC 2.1.2.11
- EC 3.4.21.68
- hN1
- Notch (Drosophila) homolog 1 (translocation-associated)
- notch 1Notch homolog 1, translocation-associated (Drosophila)
- Notch homolog 1, translocation-associated
- TAN1neurogenic locus notch homolog protein 1
- Translocation-associated notch protein TAN-1
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Bioinformatics Tool for Notch-1
Discover related pathways, diseases and genes to Notch-1. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
Related Notch-1 Blog Posts
Check out the latest blog posts on Notch-1.
Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process... Read more.
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Read more Notch-1 related blogs.