Hu, Mu, Rt(-)Applications:
WB, Flow, ICC/IF, IHC, IHC-P, IP, CyTOF-ready, KOHost:
WB, Simple Western, ICC/IF, IHC, IHC-PHost:
WB, Flow, IHC, B/N, CyTOF-ready, ICC/IFHost:
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.
|Product By Gene ID
- EC 188.8.131.52
- Notch (Drosophila) homolog 1 (translocation-associated)
- EC 184.108.40.206
- Notch homolog 1, translocation-associated
- Translocation-associated notch protein TAN-1
- TAN1neurogenic locus notch homolog protein 1
- notch 1Notch homolog 1, translocation-associated (Drosophila)
Bioinformatics Tool for Notch-1
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|Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process... Read more.