Notch-1 Products

Antibodies
ELISA Kits
Notch-1 ELISA Kit [Biotin]
Notch-1 ELISA Kit [Biotin]
KA2219
Species: Hu
Lysates
Notch-1 Overexpression Lysate ...
Notch-1 Overexpression Lysate (Nat...
NBL1-13725
Applications: WB
Proteins
Notch-1 Partial Recombinant P ...
Notch-1 Partial Recombinant Protein
H00004851-Q01
Species: Hu
Applications: WB, ELISA, PA
Notch-1 Peptide
Notch-1 Peptide
NBP1-96995
Applications: WB, ELISA, IP
Notch-1 Peptide
Notch-1 Peptide
NB300-251PEP
Species: Hu
Applications: AC
RNAi
Notch-1 RNAi
Notch-1 RNAi
H00004851-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.

Bioinformatics

Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 4851
Alternate Names
  • EC 3.4.21.68
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • EC 2.1.2.11
  • hN1
  • Notch homolog 1, translocation-associated
  • Translocation-associated notch protein TAN-1
  • TAN1neurogenic locus notch homolog protein 1
  • notch 1Notch homolog 1, translocation-associated (Drosophila)

Research Areas for Notch-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Neuroscience
Signal Transduction
Stem Cell Signaling Pathway

Bioinformatics Tool for Notch-1

Discover related pathways, diseases and genes to Notch-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Notch-1 Blog Posts

Check out the latest blog posts on Notch-1.
Notch1 - A multifunctional transmembrane receptor
Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...    Read more.
Read more Notch-1 related blogs.