Notch-1 Products

Description

Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane which then translocates to the nucleus to activate transcription of downstream genes.

Bioinformatics

Uniprot	NM_017617 Human NP_060087 Human P46531 (human) Human P46531 Human Q01705 Mouse
Product By Gene ID	4851
Alternate Names	EC 2.1.2.11 EC 3.4.21.68 hN1 Notch (Drosophila) homolog 1 (translocation-associated) notch 1Notch homolog 1, translocation-associated (Drosophila) Notch homolog 1, translocation-associated TAN1neurogenic locus notch homolog protein 1 Translocation-associated notch protein TAN-1

Diseases related to Notch-1

Discover more about diseases related to Notch-1.

Neoplasms
Malignant Neoplasms
Leukemia
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Cell Transformation, Neoplastic
Acute Lymphocytic Leukemia
Carcinoma
Lymphoma
Nervousness
Tumor Angiogenesis
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Mammary Neoplasms
Alzheimer's Disease
Neoplasm Metastasis
Adult T-cell Lymphoma/leukemia
Leukemogenesis
Leukemia, T-cell
Hyperplasia
Cell Invasion

Pathways for Notch-1

View related products by pathway and learn more about each of the pathways below.

Notch Signaling Pathway
Cell Proliferation
Cell Differentiation
Pathogenesis
Cell Cycle
Cell Growth
Neurogenesis
Cell Development
Angiogenesis
Localization
Cell Fate Determination
Cell Death
Regeneration
Proteolysis
Cell Cycle Arrest
Rna Interference
Secretion
Oncogenesis
Cell Migration
Somitogenesis

Research Areas for Notch-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Neuroscience
Signal Transduction
Stem Cell Signaling Pathway

PTMs for Notch-1

Learn more about PTMs related to Notch-1.

Cleavage
Phosphorylation
Methylation
Ubiquitination
Glycosylation
Acetylation
Hydroxylation
Reduction
Biotinylation
Demethylation
Gamma-cleavage
Dephosphorylation
Ubiquitinylation
Nitration
Farnesylation
Deacetylation
Oxidation

Bioinformatics Tool for Notch-1

Discover related pathways, diseases and genes to Notch-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related Notch-1 Blog Posts

Check out the latest blog posts on Notch-1.

Notch1 - A multifunctional transmembrane receptor Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental process...    Read more.

Read more Notch-1 related blogs.