Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Pm, Xp
Applications: WB
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
28512 |
| Alternate Names |
- I-kappa-B-interacting Ras-like protein 1
- kappa B-ras 1
- Kappa B-Ras protein 1
- KappaB-Ras1
- KBRAS1kappaB-Ras1
- NF-kappa-B inhibitor-interacting Ras-like protein 1
- NFKB inhibitor interacting Ras-like 1
- NFKB inhibitor interacting Ras-like protein 1
|
Research Areas for NKIRAS1
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
