NIPA Products

Antibodies
NIPA Antibody
NIPA Antibody
NBP1-82564
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
NIPA Antibody
NIPA Antibody
NBP1-82565
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
NIPA Antibody
NIPA Antibody
NBP1-19525
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
NIPA Overexpression Lysate (N ...
NIPA Overexpression Lysate (Native)
NBP2-07034
Applications: WB
NIPA Overexpression Lysate (D ...
NIPA Overexpression Lysate (Denatu...
H00051530-T01
Applications: WB
Proteins
NIPA Recombinant Protein
NIPA Recombinant Protein
H00051530-P01
Species: Hu
Applications: WB, ELISA, PA
NIPA Recombinant Protein
NIPA Recombinant Protein
H00051530-P02
Species: Hu
Applications: WB, ELISA, PA
NIPA Recombinant Protein Anti ...
NIPA Recombinant Protein Antigen
NBP1-82564PEP
Species: Hu
Applications: AC

Description

Entry into mitosis is essentially driven by cyclin B1, which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear interaction partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation. Therefore, the accumulation of cyclin B1 is due to the inability of phosphorylated NIPA to bind to the molecule SCF, thereby preventing the degradation of cyclin B1. An absence of NIPA causes cyclin B1 to accumulate abnormally, leading to premature mitotic entry, loss of checkpoint control and genomic instability, which are all associated with cancer. The phosphorylated form of NIPA may also be involved in apoptotic signaling pathways.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 51530
Alternate Names
  • FBXO50
  • C3HC type 1
  • zinc finger, C3HC-type containing 1

Pathways for NIPA

View related products by pathway and learn more about each of the pathways below.

Interphase
Mitosis
Cell Cycle
Reverse Transcription
G2 Phase
Endocytosis
Pathogenesis
Localization

PTMs for NIPA

Learn more about PTMs related to NIPA.

Phosphorylation
Ubiquitination

Bioinformatics Tool for NIPA

Discover related pathways, diseases and genes to NIPA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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