Nicalin Products

Antibodies
Nicalin Antibody
Nicalin Antibody
NBP1-81002
Species: Hu, Mu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Nicalin Antibody
Nicalin Antibody
AF7686
Species: Hu, Mu, Rt
Applications: WB
Host: Sheep Polyclonal
Nicalin Antibody
Nicalin Antibody
NBP2-19493
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Proteins
Nicalin Recombinant Protein
Nicalin Recombinant Protein
H00056926-P01
Species: Hu
Applications: WB, ELISA, PA
Nicalin Partial Recombinant P ...
Nicalin Partial Recombinant Protein
H00056926-Q01
Species: Hu
Applications: WB, ELISA, PA
Nicalin Recombinant Protein A ...
Nicalin Recombinant Protein Antigen
NBP1-81002PEP
Species: Hu
Applications: AC
RNAi
Nicalin RNAi
Nicalin RNAi
H00056926-R01
Species: Hu

Description

Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a Nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGFbeta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the Nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 56926
Alternate Names
  • nicalin homolog (zebrefish)
  • nicalin homolog (zebrafish)
  • Nicastrin-like protein
  • NET59
  • NICALIN
  • nicalin

Diseases related to Nicalin

Discover more about diseases related to Nicalin.

Neoplasms
Neoplasms, Experimental
Alzheimer's Disease

Pathways for Nicalin

View related products by pathway and learn more about each of the pathways below.

Rna Interference

PTMs for Nicalin

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Cleavage

Bioinformatics Tool for Nicalin

Discover related pathways, diseases and genes to Nicalin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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