Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, ELISA, Func, ICC/IF, IHC, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Fe
Applications: WB, ELISA, ICC/IF, IHC, IHC
Host: Chicken Polyclonal
Species: Ma
Applications: WB, Func, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Neuronal intermediate filaments (NIF) are found specifically on neurons where they play key role in maintaining neuronal morphology as well as in regenerating myelinated axons. NIF contain three subunits: a light polypeptide (NEFL/NFL), a medium polypeptide (NEFM/NFM), and a heavy polypeptide (NEFH/NFH), with molecular weights of 68, 160, and 212 kD respectively. 200kD neurofilament heavy (NEFH) is one of the major components of neuronal cytoskeleton NIF and NEFH gene was originally proposed as a DNA marker for presymptomatic diagnosis in neurofibromatosis type 2 (NF2). NEHF facilitate interactions between NIF and brain mitochondria with binding efficiency dependent upon mitochondrial membranes potential. NEFH and beta-catenin are constituents in postsynaptic density (PSD) in CNS and NEFH is essential for maintaining normal cell integrity. Diminished NEFH levels are seen in certain cancers including human autonomic nerve tumors or central neurocytomas, prostate cancer, clear-cell epithelioid tumor and small cell lung carcinoma. Fibroblasts overexpressing NEFH are distorted, multinucleated, and possess inclusions, typical changes seen in neuropathies, and defects in NEFH are linked to susceptibility to ALS.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
4744 |
| Alternate Names |
- 200 kDa neurofilament protein
- KIAA0845
- NEFH
- Neurofilament Heavy (200kDa)
- neurofilament heavy polypeptide
- Neurofilament triplet H protein
- neurofilament, heavy polypeptide 200kDa
- neurofilament, heavy polypeptide
- NF200
- NFH
- NF-H
|
![ELISA Human NF-H [p Ser668, p Ser702] ELISA Kit (Colorimetric)](http://images.novusbio.com/fullsize/nbp2-78763_human-nf-h-p-ser668-p-ser702-elisa-kit-colorimetric-132202416184833.jpg)
![ELISA Human NF-H [p Ser668, p Ser702] ELISA Kit (Colorimetric)](http://images.novusbio.com/fullsize/nbp2-78763_human-nf-h-p-ser668-p-ser702-elisa-kit-colorimetric-432024955077.jpg)
