NEK9 Products

Description

NEK9, a NEK type protein kinase, regulates chromosome alignment and segregation in mitosis. The protein has a N-terminal NIMA-like catalytic domain, a central domain with homology to the guanine nucleotide exchange factor for the GTPase Ran (RCC1), and a C-terminal coiled-coil domain. It is phosphorylated by active p34(Cdc2) and is capable of autophosphorylation and oligomerization. The activated protein binds Nek6 and RCC1, and has been shown to associate with the human homolog of the Drosophila protein Bicaudal D (Bicd2) in vivo and to phosphorylate this coiled-coil protein in vitro. NEK9 expression has been documented in normal human brain. ESTs have been isolated from several tissue libraries, including normal bone, lymph and thymus and cancerous cervix, eye, lymph and placenta.

Bioinformatics

Entrez	91754 Human
Product By Gene ID	91754
Alternate Names	DKFZp434D0935 KIAA1995 MGC138306 MGC16714 Nek8 Nek8NERCC1 NEK9 NERCC Nercc1 kinase NERCCEC 2.7.11.1 Never in mitosis A-related kinase 9 NIMA (never in mitosis gene a)- related kinase 9 NimA-related kinase 8 NIMA-related kinase Nek8 NimA-related protein kinase 9 serine/threonine-protein kinase Nek9

Research Areas for NEK9

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
DNA Repair