NEDD8 Products

Description

NEDD8 (Neural precursor cell-Expressed Developmentally Down-regulated genes) is an ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis (1). NEDD8 has been shown to conjugate to nuclear proteins in a manner analogous to ubiquination and sentrinization. The conjugation process is though to be catalyzed by thee enzymes; E1 (NEDD8-activation), E2 (NEDD8-conjugation) and E3 (NEDD8-ligation). NEDD8 is known to conjugate to Cul-4A and other cullins proteins via the carboxy-terminal Gly residue for ubiquitinylation (3) while NUB1 will negatively regulate its expression (4).

Bioinformatics

Uniprot	NP_006147 Human NP_006147.1 Human Q15843 Human
Product By Gene ID	4738
Alternate Names	FLJ43224 MGC104393 MGC125896 MGC125897 Nedd-8 NEDD-8 neddylin Neddylin Neural precursor cell expressed developmentally down-regulated protein 8 neural precursor cell expressed, developmentally down-regulated 8 Ubiquitin-like protein Nedd8

Research Areas for NEDD8

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Cancer

Related NEDD8 Blog Posts

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PINK1: All work and no fun The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.

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