NDUFA1 Products

Description

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.

Bioinformatics

Entrez	4694 Human
Uniprot	AAH00266 Human
Product By Gene ID	4694
Alternate Names	CI-MWFEcomplex I MWFE subunit Complex I-MWFE MWFENADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa NADH oxidoreductase subunit MWFE NADH:ubiquinone oxidoreductase (complex 1) NADH-ubiquinone oxidoreductase MWFE subunit type I dehydrogenase ZNF183

Related NDUFA1 Blog Posts

Check out the latest blog posts on NDUFA1.

Mechanisms of Neurodegeneration: Mitochondrial Dysfunction and Oxidative Stress By Michalina Hanzel, PhDIn this second installment of our three blog-posts series on major cellular mechanisms responsible for neurodegenerative disorders, we will explore the processes of mitochondrial dysfunction an...    Read more.

Read more NDUFA1 related blogs.